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Geographic disparities are pronouncedNorth Africa and the Middle East show the highest prevalence, while data remain sparse in lowincome regions [35, 38]

Imaging MEV samples with AFM requires detailed reporting of the initial sample deposition technique, substrate type, preliminary procedures, immobilization methods, sample concentration and deposition times, rinsing and/or drying steps, AFM visualization mode, acquisition conditions, and probe information [264]

The combination of N-terminal amine, histidine at position 2, and intervening amide nitrogen is a recurrent high-affinity copper-binding motif in peptide biochemistry the same general motif also appears in human serum albumin's N-terminal copper-binding site